This project will employ a range of advanced microbial ecology and molecular biology techniques to evaluate the impact of nervous system-targeted drugs on the human gut microbiome composition and activity. It will also investigate the role of the microbiome on the efficacy of neuromodulating drugs.
人类的肠道是数万亿微生物的家园, 通常被称为肠道菌群. Alterations of the gut microbiome are associated with neurological 条件 including autism spectrum disorder, 抑郁症, 帕金森氏症和老年痴呆症, and accumulating evidence demonstrates that the gut microbiota and its metabolites affect brain function and behaviour via the microbiota–gut–brain axis.
Therapy for neurological diseases such as Parkinson's or 抑郁症 often include the use of drugs that modulate the levels of key neurotransmitters in the brain. 因为这些药物是口服的, 它们与肠道中数千种微生物相互作用. 事实上, 药物治疗, 包括神经系统药物, 是否被证明对肠道微生物组的组成有重大影响. 然而, the direct impact of neuromodulating drugs on the metabolism of human gut microbiota is unclear.
This project aims to evaluate the impact of nervous system-targeted drugs on the human gut microbiome composition and activity. We will also investigate how the microbiome influences host response to nervous system-targeted drugs. This is an exciting opportunity to break new ground in our understanding of how drugs and bugs interact and can potentially lead to the identification of key microbiome players that can be manipulated to augment the efficacy of current therapies for neurological disease.
We are looking for a student with a strong interest in microbiology and who is keen to learn some bioinformatics. 解决提出的研究问题, you will receive training in and apply a range of microbial ecology and advanced molecular biology techniques including anaerobic cultivation, 细菌基因, 使用示踪剂检测微生物活性, 荧光激活细胞分选, 还有宏基因组学和生物信息学.